Synthesis and Pharmacological Investigation of Novel 2-(3-hydroxy-4-methoxy Phenyl)- 3-substituted-thiazolidin-4-ones as Anticonvulsants
نویسندگان
چکیده
A new series of 2,3-disubstituted thiazolidin-4-ones were obtained by the condensation of appropriate amines with vanillin and mercapto acetic acid in the presence of DCC in anhydrous THF by microwave irradiation. The title compounds were investigated for their anticonvulsant activity. Among the test compounds, compound N-(2-(3hydroxy-4-methoxyphenyl)-4-oxo thiazolidin-3-yl) isonicotinamide (3) emerged as most active compound of the series and it is moderately more potent than the reference standard diazepam.
منابع مشابه
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